Mathematical Modelling in Nature, Life, and Science
Saturday, April 20, 2013
DNA-Polymer nanoparticle are used to deliver DNA to cell nuclei for curing diseases at the genetic level. In my research group, we work with carboxy-betaine acrylamide polymers. I modeled an exceptionally large DNA-polymer nanoparticle below. The polymer is 80 kDa and the DNA is a single strand of 65 base pairs. After condensing it (in blender, not a true physical simulation), the nanoparticle comes out to about 15nm in diameter.